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University of Gothenburg
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Omega-3/Omega-6 Fatty Acids for Attention Deficit Hyperactivity Disorder: A Randomised Placebo-Controlled Trial in Children and Adolescents

Participants: Mats Johnson, Gunnar Fransson, Sven Östlund, Björn Kadesjö & Christopher Gillberg.

Background: Omega-3 fatty acids have recently attracted interest as a possible adjunct in the treatment of attention-deficit/hyperactivity disorder (ADHD).

Methods: The study assessed treatment with omega 3/6 fatty acids (eye q) for ADHD, in a randomised, three-month placebo-controlled, one-way crossover trial with 75 children and adolescents (8–18 years), followed by three months open label with omega 3/6 for all. Outcome measures were the investigator-rated ADHD Rating Scale-IV and Clinical Global Impression (CGI) scale.

Results: A majority did not respond to omega 3/6 treatment. However, a subgroup of 26% responded with more than 25% reduction of ADHD symptoms and a drop of CGI scores to the near-normal range. After six months, 47% of all showed such improvement. Responders tended to have ADHD inattentive subtype and comorbid neurodevelopmental disorders (ESSENCE).


Johnson, M., Östlund, S., Fransson, G., Kadesjö, B., & Gillberg, C. (2009). Omega-3/omega-6 fatty acids for attention deficit hyperactivity disorder: a randomized placebo-controlled trial in children and adolescents. Journal of Attention Disorders, 12, 394-401.


Page Manager: Anna Spyrou|Last update: 1/16/2013

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