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Neurodevelopment in Febrile Seizures and Childhood Epilepsy: Data from a Population-Based Swedish Twin Cohort

Participants: Colin Reilly, Sebastian Lundström , Elisabeth Fernell, Christopher Gillberg et al.

Background: There is a well-documented association between childhood epilepsy and ESSENCE but the relationship between febrile seizures (FS) and Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations (ESSENCE) is less clear. The majority of population-based studies have not shown an increase in ESSENCE type difficulties in FS, although one previous population-based study suggests a possible increase in ADHD in FS.

Methods: The Child and Adolescent Twin Study in Sweden (CATSS) is an ongoing population–based study targeting twins born in Sweden since July 1, 1992. This study involves:

• Parents of 27,092 twins being interviewed using a validated DSM-IV based interview (Autism-Tics, ADHD and other Comorbidities inventory, A-TAC) for ESSENCE, on their 9th or 12th birthday. ESSENCE problems considered were Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD), Learning Difficulty (LD) and Developmental Coordination Disorder (DCD).
• Diagnoses of epilepsy (n=282) and FS (n=492) are based on the Swedish National Patient Register (NPR).
• Prevalence of ESSENCE in epilepsy and FS will be compared with prevalence in the total twin population.
• The association between FS and ESSENCE will be considered before and after adjustment for epilepsy.
• Age of diagnosis of FS/epilepsy will be considered as a possible correlate of ESSENCE in FS and epilepsy.

Results: Results will be available in 2017.
 

Page Manager: Anna Spyrou|Last update: 4/15/2016
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